The Sharks head into the Dragons derby after winning 9 of their last 10 matches, but they must avoid complacency.
St George faces a tough situation, having lost three straight and sitting at the bottom of the NRL ladder, although they surprised the Sharks with a 22-14 win last season from a similar position.
This rivalry has produced many intense battles over the years for the Monty Porter Memorial Cup, and with Indigenous Round adding significance, the clash could become even more emotional.
Mawene Hiroti will take his place in the centres, stepping in for KL Iro, who is sidelined due to a concussion.
There's also a possibility that Michael Gabrael will make his NRL debut; he's been named at jumper 18 on the six-man bench.