In a clash of the league's top teams, the Panthers are set to face the revitalized Sea Eagles.
Since Kieran Foran stepped in as interim coach in Round 5, Manly has maintained an impressive unbeaten streak, aiming for a fifth consecutive victory at CommBank Stadium.
However, the Panthers will pose their stiffest test yet, as their only loss this season to the Bulldogs seems increasingly insignificant-though the Dolphins did challenge them in Darwin.
Last week, Penrith showcased their dominance by overwhelming the Knights, with Dylan Edwards scoring a hat-trick just 20 minutes into the match, sealing the outcome early.