Papua New Guinea's World Cup campaign opens against Lebanon in Port Moresby on October 17, with coach Jason Demetriou facing several high-profile absences.
Gold Coast forward Cooper Bai is out with a hamstring injury, while Leigh halfback Lachlan Lam will miss the tournament for wrist surgery.
Wingers Alex Johnston and Xavier Coates are also unavailable, leaving the Kumuls with a depleted squad for their opener.
Parramatta veteran Jack de Belin is among the NRL-experienced players selected.
Uncapped Manly centre Josh Feledy and Eels prop Luca Moretti have earned places, alongside North Queensland backs Zac Laybutt and Robert Derby.
Bailey Biondi-Odo, who played 17 matches for Canterbury, is included after signing with the Warriors for 2027.
Super League veterans Rhyse Martin and Nene Macdonald also feature in a squad largely drawn from England's lower divisions and the Queensland Cup.
After Lebanon, Papua New Guinea host Samoa, then travel to Wollongong to face England in their final group-stage match.