The NSWRL will seek John Strange's successor before the Blues' March camp, ahead of their April 30 series opener in Newcastle.
Strange's departure ends a two-year tenure that began in 2025.
Before his appointment, NSW had won just one of the previous five series.
He leaves after two series victories, including the first whitewash in a three-game women's series earlier this year.
Strange won five of six Origin games while balancing the role with commitments to the Sydney Roosters' premiership-winning NRLW side.
Strange said, "I am incredibly proud of what we have achieved, but even prouder of the players and staff that make this group so special,"
"I will take away some fantastic memories and relationships that will last a lifetime."
NSWRL chief executive David Trodden said, "John changed the trajectory of the women's State of Origin program,"
Trodden added, "He instilled a winning culture amongst the NSW women's group."