Scott Sorensen and Liam Henry have been named to start after late changes by Ivan Cleary for Penrith's preliminary final.
Nathan Cleary will begin on the interchange bench, with Jack Cogger named at halfback.
The Panthers have not specified Cleary's expected role, leaving open whether he will provide emergency cover or enter the game later.
Cleary has a stress-related bone issue in his foot, confirmed after Penrith's Week 1 win over the Roosters.
He appeared uncomfortable late in that match and then had two weeks to recover ahead of the preliminary final.
His bench selection suggests the injury remains a concern despite the match's importance and his standing as a leading player.
The 4pm preliminary final will determine who meets the Roosters in the Grand Final on Sunday week.