Dylan Edwards will miss the upcoming World Cup after a knee injury, Code Sports reported.
The Penrith fullback injured his posterior cruciate ligament in the first half of last week's preliminary final loss to Newcastle.
He was visibly troubled by the injury and struggled to move laterally while carrying the ball.
Edwards, a four-time premiership winner, will undergo knee surgery.
His absence leaves James Tedesco and Reece Walsh competing for the Kangaroos' No. 1 jersey.
Coach Kevin Walters is expected to announce Australia's 21-man squad on Monday, with some positions still unsettled.