The NSWRL will begin searching for a new NSW women's State of Origin coach before the Blues' March training camp.
The camp will prepare the team for its series opener against Queensland in Newcastle on April 30.
John Strange has stepped down after two years in charge, during which NSW won two series and five of six Origin matches.
His final series included the first whitewash in a three-game women's series, achieved earlier this year.
Before Strange took over in 2025, the Blues had won just one of their previous five series.
The 51-year-old also coached the Sydney Roosters' premiership-winning NRLW side.
"I am incredibly proud of what we have achieved, but even prouder of the players and staff that make this group so special," Strange said.
"I will take away some fantastic memories and relationships that will last a lifetime."
NSWRL chief executive David Trodden said Strange had changed the program's direction and fostered a winning culture.
Trodden said Strange's record comprised five wins and one close defeat, reflecting his professionalism, high standards and commitment to representative football.
"Behind the scenes, he has been a long-term pioneer of the women's game and although we are sorry to see him go, we will forever be thankful for the lasting legacy he has left," Trodden said.