A selection panel drawn from coaches, players, administrators, journalists and commentators worldwide chose 42 inductees from more than 240 nominees for the International Rugby League Hall of Legends.
The inaugural group spans the game's earliest international years through to current star Jason Taumalolo, with representatives from eight nations.
It includes 10 players from before 1954, six women's game greats and 26 male players from the post-1954 era.
Rabbitohs legends Clive Churchill and Ron Coote, both Immortals, will be honoured at a ceremony at Suncorp Stadium on Thursday, before this weekend's Rugby League World Cup finals.
They join fellow Immortals Wally Lewis, Mal Meninga, Andrew Johns, Reg Gasnier, John Raper, Graeme Langlands, Bob Fulton and Arthur Beetson.
The inductees also include modern Kangaroos greats Darren Lockyer, Brad Fittler, Cameron Smith, Johnathan Thurston and Billy Slater.