Sharks centre Jesse Ramien faces a month out due to a Grade 2 medial collateral ligament injury.
The injury occurred during the second half of the Easter Sunday match against the Warriors, where he exited the field in the 59th minute.
Mawene Hiroti will step in for Ramien during the upcoming game against the Roosters in Perth.
Meanwhile, young outside back Michael Gabrael is also on the sidelines, dealing with a similar knee injury from his match with the Newtown Jets last week.
He is currently waiting for test results that will provide clarity on his return timeline.
Additionally, front-rower Braden Uele has been ruled out this weekend due to a concussion sustained in the NSW Cup.